Current Problems in Diagnostic Radiology
Volume 37, Issue 3 , Pages 104-114 , May 2008

Primary Hepatocellular Lesions: Imaging Findings on State-of-the-Art Magnetic Resonance Imaging, with Pathologic Correlation

  • Indra C. van den Bos, MD, PhD

      Affiliations

    • Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    • Corresponding Author InformationReprint requests: Indra C. van den Bos, MD, PhD, Department of Radiology, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
  • ,
  • Shahid M. Hussain, MD, PhD

      Affiliations

    • Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    • Department of Radiology, University of Nebraska Medical Center, Omaha, NE
  • ,
  • Robert A. de Man, MD, PhD

      Affiliations

    • Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
  • ,
  • Pieter E. Zondervan, MD

      Affiliations

    • Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
  • ,
  • Jan N.M. IJzermans, MD, PhD

      Affiliations

    • Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • ,
  • Gabriel P. Krestin, MD, PhD

      Affiliations

    • Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

References 

  1. Hussain SM, Semelka RC. Hepatic imaging: Comparison of modalities. Radiol Clin North Am. 2005;43:929–947ix
  2. Hussain SM. Liver MRI: Correlation with other imaging modalities and histopathology. Heidelberg: Springer-Verlag; 2007;
  3. Burt A, Day C. Pathophysiology of the liver. In:  MacSween RNM,  Burt AD,  Portmann BC, et al. editor. Pathology of the Liver. Glasgow, UK: Churchill Livingstone; 2002;p. 67–104
  4. Jeong YY, Mitchell DG, Holland GA. Liver lesion conspicuity: T2-weighted breath-hold fast spin-echo MR imaging before and after gadolinium enhancement—initial experience. Radiology. 2001;219:455–460
  5. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology. 1995;22:983–993
  6. Hussain SM, Zondervan PE, IJzermans JNM, et al. Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation. Radiographics. 2002;22:1023–1036discussion 1037-29
  7. Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology. 1985;5:1194–1200
  8. Gyorffy EJ, Bredfeldt JE, Black WC. Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use. Ann Intern Med. 1989;110:489–490
  9. Ito K, Mitchell DG, Hann HW, et al. Viral-induced cirrhosis: Grading of severity using MR imaging. AJR. 1999;173:591–596
  10. Ito K, Mitchell DG, Gabata T, et al. Expanded gallbladder fossa: Simple MR imaging sign of cirrhosis. Radiology. 1999;211:723–726
  11. Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: Adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol. 1991;22:172–178
  12. Hussain SM, Semelka RC. Liver masses. Magn Reson Imaging Clin North Am. 2005;13:255–275
  13. Jeong YY, Yim NY, Kang HK. Hepatocellular carcinoma in the cirrhotic liver with helical CT and MRI: Imaging spectrum and pitfalls of cirrhosis-related nodules. AJR. 2005;185:1024–1032
  14. Mitchell DG, Rubin R, Siegelman ES, et al. Hepatocellular carcinoma within siderotic regenerative nodules: Appearance as a nodule within a nodule on MR images. Radiology. 1991;178:101–103
  15. van den Bos IC, Hussain SM, Terkivatan T, et al. Stepwise carcinogenesis of hepatocellular carcinoma in the cirrhotic liver: Demonstration on serial MR imaging. J Magn Reson Imaging. 2006;24:1071–1080
  16. El-Serag HB. Hepatocellular carcinoma: Recent trends in the United States. Gastroenterology. 2004;127:S27–S34
  17. Fattovich G, Stroffolini T, Zagni I, et al. Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology. 2004;127:S35–S50
  18. Braga L, Guller U, Semelka RC. Modern hepatic imaging. Surg Clin North Am. 2004;84:375–400
  19. Mendez Romero A, Wunderink W, Hussain SM, et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase I-II study. Acta Oncol. 2006;45:831–837
  20. Sangro B, Mazzollini G, Prieto J. Future therapies for hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2005;17:515–521
  21. Bosch FX, Ribes J, Cleries R, et al. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005;9:191–211v
  22. van den Bos IC, Hussain SM, Dwarkasing RS, et al. MR imaging of hepatocellular carcinoma: Relationship between lesion size and imaging findings, including signal intensity and dynamic enhancement patterns. J Magn Reson Imaging. 2007;26:1548–1555
  23. Verhoef C, de Man RA, Zondervan PE, et al. Good outcomes after resection of large hepatocellular carcinoma in the non-cirrhotic liver. Dig Surg. 2004;21:380–386
  24. Rooks JB, Ory HW, Ishak KG, et al. Epidemiology of hepatocellular adenoma (The role of oral contraceptive use). JAMA. 1979;242:644–648
  25. Edmondson HA, Henderson B, Benton B. Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med. 1976;294:470–472
  26. Hussain SM, van den Bos IC, Dwarkasing RS, et al. Hepatocellular adenoma: Findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis. Eur Radiol. 2006;16:1873–1886
  27. Tao LC. Are oral contraceptive-associated liver cell adenomas premalignant?. Acta Cytol. 1992;36:338–344
  28. Prasad SR, Wang H, Rosas H, et al. Fat-containing lesions of the liver: Radiologic-pathologic correlation. Radiographics. 2005;25:321–331
  29. Anthony PP. Tumours and tumour-like lesions of the liver and biliary tract: Aetiology, epidemiology and pathology. In:  MacSween RNM,  Burt AD,  Portmann BC, et al. editor. Pathology of the Liver. Glasgow, UK: Churchill Livingstone; 2002;p. 711–775
  30. van den Bos IC, Hussain SM, Zondervan PE, et al. Hepatocellular adenoma and the surrounding liver: A spectrum of characteristic findings at state-of-the-art MR imaging, with histopathological correlation. International Society for Magnetic Resonance in Medicine, 14th Scientific Meeting and Exhibition, Seattle, WA, 2006. Proc Intl Soc Mag Reson Med. 2006;2432
  31. Nguyen BN, Flejou JF, Terris B, et al. Focal nodular hyperplasia of the liver: A comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol. 1999;23:1441–1454
  32. Hussain SM, Terkivatan T, Zondervan PE, et al. Focal nodular hyperplasia: Findings at state-of-the-art MR imaging, US, CT, and pathologic analysis. Radiographics. 2004;24:3–17discussion 18-9
  33. Terkivatan T, van den Bos IC, Hussain SM, et al. Focal nodular hyperplasia: Lesion characteristics on state-of-the-art MRI including dynamic gadolinium-enhanced and superparamagnetic iron-oxide-uptake sequences in a prospective study. J Magn Reson Imaging. 2006;24:864–872
  34. Manfredi R, Barbaro B, Masselli G, et al. Magnetic resonance imaging of cholangiocarcinoma. Semin Liver Dis. 2004;24:155–164

PII: S0363-0188(07)00044-8

doi: 10.1067/j.cpradiol.2007.07.003

Current Problems in Diagnostic Radiology
Volume 37, Issue 3 , Pages 104-114 , May 2008